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The Exquisite Machine: The New Science of the Heart

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How the heart works, how it fails and what can be done about it. A remarkable read from a world renowned researcher." The book also draws parallels between cardiac and brain research, highlighting the brain’s adaptability through neuroplasticity. The author underscores the heart’s impressive capacity to adapt and change in size and function to meet the body’s demands, even without full regeneration. Sian E. Harding currently holds the position of Professor of Cardiac Pharmacology at Imperial College London’s National Heart and Lung Institute. Additionally, she serves as the Director of the Imperial Cardiac Regenerative Medicine Centre. Her academic journey includes earning a Ph.D. in Pharmacology from King’s College, London, in 1981. Throughout her career, her primary research focus has revolved around studying the functionality of cardiomyocytes in heart failure. Roy Taylor, Professor of Medicine and Metabolism, University of Newcastle, and author of Life Without Diabetes

The Framingham Heart Study started in 1948 and managed to recruit an impressive 5,209 of the town’s 10,000 adult citizens, with ages ranging from 28-62 years and, pleasingly, with almost equal numbers of men and women…The researchers drawing from its data were the first to show many things we now take for granted: that high blood pressure, smoking, diabetes, or high cholesterol increase heart disease; that there are differences in cardiovascular risk between men and women; that exercise, a moderate body weight, and healthy eating are beneficial.” Roy Taylor, Professor of Medicine and Metabolism, University of Newcastle, and author of Life Without DiabetesRemarkably, many Takotsubo patients recover fully, going from acute heart failure to leaving the hospital disease-free within days. The condition is often triggered by extreme stressors, including arguments, bereavement, and even sporting events, with men and women responding differently to such stressors. The precise causes and mechanisms of Takotsubo syndrome remain a subject of study, and its recognition has grown worldwide, thanks to advanced imaging techniques that help diagnose the condition. MIT Press began publishing journals in 1970 with the first volumes of Linguistic Inquiry and the Journal of Interdisciplinary History. Today we publish over 30 titles in the arts and humanities, social sciences, and science and technology.

The last couple chapters deal largely with the future of heart repair through genetic / biological means (as opposed to via mechanical hearts and technologies, which are dealt with in Chapter nine.) This is where the book gets to be a challenging read for a readership of non-experts. It gets technical and jargon- / acronym-heavy.The book reveals how carbon dating, a technique typically associated with archaeology, provided essential insights into the heart’s regeneration capabilities. It was discovered that around half of the cardiomyocytes in a 75-year-old person’s heart had been present throughout their entire life, attesting to the heart’s remarkable endurance. Although there is a small degree of regeneration, especially in younger individuals, it falls short in cases of severe cardiac disease. The human heart beats with astounding precision, pulsating approximately 100,000 times every single day, propelling roughly 7,600 liters of blood throughout the body. It is a relentless performer, and its reliability is nothing short of remarkable. Due to the fact that an increasing number of individuals are expected to live beyond 100 years old, there is a growing need for cutting-edge scientific advancements in the field of heart rejuvenation. With each new AI and ML related paper the field is making significant advancements, while leaving a trace of shimmering examples and goodies behind, that tell tales of great futures. But, with such developments at this rate, it can be difficult to make sense of this creative ally/muse/friend, and how we can function together. Think of this program as an artistic exploration of the multiple fields that current developments touch upon, and an opportunity to weld them together into a collaborative art piece. We’ll not only learn how words, vocals and visuals can be generated but discuss why. In the end, artificial intelligence is very much designed by us, and dependant on our direct and indirect input.

Experiments have even demonstrated that emotional states can change within a single resting heartbeat, emphasising the heart’s role in shaping our emotional responses. For example, during heart contraction, fear responses are amplified, while during heart relaxation, they are dampened. Such findings shed light on how our bodies, bypassing conscious cognitive processes, can swiftly respond to perceived threats, offering a potential advantage in moments of danger. Interestingly, responses to images of faces expressing disgust, happiness, or neutrality vary, underscoring the heart’s unique influence on specific emotional reactions, especially in the face of potential threats. Sian Harding has been researching the causes of heart failure for 40 years, and has become more and more impressed at the astounding construction of the heart and its deep resilience. In fact, it is the very perfection of the heart that resists all our attempts to repair it, and is the challenge for the new technologies like gene therapy, tissue engineering or building a mechanical heart. Established in 1962, the MIT Press is one of the largest and most distinguished university presses in the world and a leading publisher of books and journals at the intersection of science, technology, art, social science, and design. Professor Harding is former President of the European Section of the International Society for Heart Research and Board member of the British Society of Gene and Cell Therapy. She was Special Advisor to the House of Commons Science and Technology Committee on Regenerative Medicine. Elisabeth Ehler, Professor of Cardiac Cell Biology, King's College London, author of Cardiac Cytoarchitecture

The New Science of the Heart

How the heart works, how it fails and what can be done about it. A remarkable read from a world renowned researcher.” In one of the initial chapters of the book, Dr. Harding explores the incredible resilience of the human heart in the face of various insults, both ancient and modern. Despite enduring numerous challenges, including the limited ability to regenerate its muscle cells, the heart continues to function admirably. The book is a potpourri of many different topics and while all of them are great to read about, I found them to be a bit unstructured at times (the later chapters less so).

A remarkable book that presents the miraculous reality that is our heart in spellbinding clarity. Elucidating the incredible dialogue between its beating cells to the rapidly advancing realm of personalized medicine, Sian Harding draws on her vast experience as one of the world's top cardiac scientists, writing with precision, yet simultaneously creating a book that is compelling & accessible to all." This lively account on recent advances in heart research stands out by its accessibility to a broader audience – I just loved her analogies to pastry or 'the heart as a city'!" In week two, we'll get into a deeper discussion and review of dataset collection. We'll begin initial training in Playform, have an brief introduction to GPT-2/J, and have conversations relating to manifests/words of importance for the future.MIT Press Direct is a distinctive collection of influential MIT Press books curated for scholars and libraries worldwide. Offers a balanced perspective by discussing both the successes and failures of research, providing an authentic portrayal of scientific inquiry. She talks about epigenetics. A generation or two after a starving generation, you're likely to get obese offspring. This bodes poorly for Africa. Professor Sian Harding - Emeritus Professor at Imperial College London. Previous Head of the Cardiovascular Division and Director of the British Heart Foundation Cardiovascular Regenerative Medicine Centre.

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