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Health4All Vitamin K2 MK7 200mcg 90 Tablets (V) Natural Vegan MK7 from Natto Beans Fermentation. High Strength k2mk7 Tablets (not Capsules) K2 Vitamin Supplements. VIT K2 mk7

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studied the role of vitamin K2 as a protective agent using clones of rat astroglioma C6 cells that were transfected with C-terminal fragment of β-amyloid precursor protein (β-CTF/C6 cell model). Forty healthy volunteers were administered 90 µg of menaquinone-7 for 30 days; and prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), blood coagulation factors II, VII, IX and X activities and protein induced by vitamin K absence or antagonist-II (PIVKA-II) were measured in blood samples. In a subsequent study, five healthy female subjects were administered with 60 μg of MK-7 daily after supper for 7 days. In MG6 cells derived from mouse microglia exposed to lipopolysaccharide, different concentrations of vitamin K2 (0–10 µM) were used; wherein the upregulation of inflammatory cytokines like IL-1β, IL-6 and TNF-α were highly suppressed at 10 μM at mRNA level.

In addition, increase in phosphorylated Smad1 level was reported in cells treated with 10 –6 M vitamin K2-7. Tray bioreactors, static deep bed bioreactors and dynamic mode fermenters that include rotating drums are some of the bioreactors used for SSF ( Mahdinia et al.

Due to the widespread use of MK-7-containing supplements, the pharmacokinetics following single intake of MK-7 from various formulations was assessed in four parallel studies. This is where the vitamin acquired its current name from since the German word starts with the letter K. The plasma levels of dephospho-uncarboxylated matrix Gla protein (dp-ucMGP) was decreased to 485 ± 30 pmol/L in the yogurt Kplus group, 417 ± 33 pmol/L in the yogurt K group and 434 ± 31 pmol/L in the capsules group. The newly synthesized osteocalcin is inactive and it requires vitamin K2-7 for converting itself into active form by carboxylation, and later bind to calcium ( Hauschka et al. An increase in yield by 2-fold was obtained compared to the fermentation medium containing untreated bacterial strain ( Ranmadugala et al.

Vitamin K2-7 or menaquinone-7, a naturally occurring form of vitamin K2, is easily absorbed and readily bioavailable compared to other forms. enhanced carboxylation of matrix Gla protein (MGP) and osteocalcin (OC), while a decrease in the levels of circulating dephospho-uncarboxylayed MGP (dp-ucMGP) and uncarboxylated osteocalcin (ucOC) as well as in the ucOC:cOC ratio was observed. With the removal of excess air and water, products require less packaging and become more efficient to dispatch.

Thus, vitamin K2-7 is thought to be involved in bone mineralization as an essential element for the γ-carboxylation of OC ( Iwamoto et al. Furthermore, MGP inhibits vascular calcification through downregulation of bone morphogenetic protein-2 (BMP-2) which promotes vascular calcification. All the existing forms of vitamin K2 consist of a common moiety in their chemical structure which is a 2-methyl-1,4-naphthoquinone ring. Depending on the dietary intake, the presence of vitamin K2-7 is also detected in human milk samples ( Marles et al. In nature, vitamin K occurs in two main forms namely, phylloquinone (vitamin K1) and various menaquinones (vitamin K2) ( Mahdinia et al.

studied the Bacillus subtilis fermentation for high production of K2-7 using biocompatible organic solvents, n-hexane and n-butanol mixture. SSF is used for the production of secondary metabolites; the raw material used here is soy protein and corn grits. Eighty-four patients undergoing RA treatment were either administered 100 µg dose of MK-7 capsules or kept naïve without changing any other medication for 3 months. A. Vitamin D3 is a fat-soluble vitamin that helps regulate calcium and phosphorous levels in the body. Osteocalcin produced by osteoblasts binds to calcium present in blood circulation and leads it to the bone matrix.

The funder had the following involvement with the study: SJ prepared Table 4 on other global clinical trials.

It was also observed that MK-7 supplementation showed a dose- and time-dependent response in dp-ucMGP and ucOC and PIVKA-II levels ( Westenfeld et al.

Thus, RANK receptor is sequestered by K2-7 preventing steps leading to osteoporosis shown in Figure 4 ( Badmaev et al.

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