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Here, we identify FHL2 as a critical regulator of hematopoietic stem cells (HSCs) that is essential for maintaining HSC self-renewal under regenerative stress. FHL2 was also shown to associate with promyelocytic leukemia zinc finger protein (PLZF), a known sequence-specific DNAbinding transcriptional repressor, and was able, in vitro, to further down-regulate target genes [29]. A strong anti-tumorigenic effect of rAAV-FHL2-shRNA was shown in nude mice and this antitumor effect was enhanced when combined with 5-FU treatment. The transcription levels of Vg and 30Kc19 were significantly downregulated following BmFhl2 overexpression in the silkworm ovarian cell line BmN.
I have been to neurologists, dermatologists, psychologists, psychiatrists, general practitioners, endochronologists, everything.It decomposes at an acidic pH in the bladder to form formaldehyde and ammonia, and the formaldehyde is bactericidal; the mandelic acid adds to this effect.
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The interaction between FHL2 and G0/G1 cell cycle and growth was evaluated by flow cytometry, western blot analysis and WST-1 assay. This study aimed to determine whether FHL2 mediated the mesenchymal cells in tooth development and human dental pulp cell differentiation into odontoblasts by interacting with Runx2. The 103 third parties who use cookies on this service do so for their purposes of displaying and measuring personalized ads, generating audience insights, and developing and improving products. Anyone who’s bouldered here in the summer knows how heinous even relatively easy sloper problems feel in the heat and humidity. Now, that wouldn’t be the worst thing if it were all roses, but like all things in life, every high has its low.