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Overall, Pepe has made over 130 appearances to date for the Portugal national team, making him one of the country's most-capped players. Fig. 4 (A) Relative ratios for the reaction of the peptides and the KeraPep at 37 °C and at 120 °C obtained by MALDI-TOF/TOF. (B) Molecular dynamics simulations of the average distances in the last 10 ns of simulation between dimers of KeraPep and the peptides PepC, PepD, PepG and KP. The images reflect the final state of the simulations. (C) Curly hair tresses before and after peptide treatments; after treatments, the hair tresses were washed and dried at 50 °C. The bottom images present the samples treated with the serum formulations containing peptides (PepE, PepG, KP) at 0.1% (w/v); the images in the middle present the samples treated with the serum formulations containing peptides (PepE, PepG, KP) at 0.01% (w/v); the images at the top show the samples treated without peptides (buffer, chemical and base serum formulation treatments). (D) Straightening efficiency of serum treatments with peptides for curly hair tresses. (E) Peptide nomenclature and characteristics: name, number of amino acids (N.a.a), molecular weight (MW), isoelectric point (pI), percentage of cysteines (Cys), percentage of hydrophobic (Hydr.) and polar amino acids in the peptide sequence, and peptide chemical structures.
The treatments with the peptides increased the mechanical properties of the hair, as measured by both the Young's modulus and stress at peak. PepA, PepB, PepC, PepD, PepE, PepF, PepG and KP improved the Young's modulus resistance by up to 40% when compared with the over-bleached hair. PepC has high attachment with a positive net charge during the hair treatments, which increases its resistance to washing and its attraction to the hair surface, especially in damaged hair due to the more negative net charge of the hair cuticle. In addition, this peptide did not show a propensity to form intramolecular disulphide bonds but was able to interact with hair proteins. Both properties contribute to the high efficiency of this peptide to improve the mechanical properties of damaged hair. PepD has a close conformation which promotes the formation of intramolecular disulphide bonds, decreasing its propensity to interact with the hair surface, resulting in low fibre uptake and low improvement of hair mechanical properties.N. Schmid, A. P. Eichenberger, A. Choutko, S. Riniker, M. Winger, A. E. Mark and W. F. van Gunsteren, Eur. Biophys. J., 2011, 40, 843–856 CrossRef CAS PubMed. M. H. Maneli, P. Smith and N. P. Khumalo, J. Am. Acad. Dermatol., 2014, 70, 276–280 CrossRef CAS PubMed. C. L. Galli, F. Bettin, P. Metra, P. Fidente, E. De Dominicis and M. Marinovich, Regul. Toxicol. Pharmacol., 2015, 72, 562–568 CrossRef CAS PubMed. Disruption of disulphide bonds and possible rearrangement to disulphide bonds or lanthionine bonds (lye relaxer with pH ≥ 12) Celestin worked and found time to go to his son’s training sessions. To be closer to his son, he went on to obtain a license as a soccer educator.
The couple tied the knot in a secret wedding ceremony in France, attended by all of their closest family and friends. Pepe has been named the Primeira Liga's Best Defender twice (in 2006 and 2007) and was included in the UEFA Champions League Squad of the Season four times (in 2013–14, 2014–15, 2015–16, and 2016–17). Fig. 2 (A) Peptide nomenclature and characteristics: name, number of amino acids (N.a.a), molecular weight (MW), isoelectric point (pI), percentage of cysteines (Cys), percentage of hydrophobic (Hydr.) and polar amino acids in the peptide sequence, and peptide chemical structures; (B) relative ratio of species determined by MALDI-TOF/TOF; (C) distance between β-carbons of the cysteines of the peptides PepC, PepD, PepG and KP in the last 50 ns of simulation. for Angers, before exploring it in person. Pépé described Bielsa as “special” and a “great coach”. He began the season playing as a striker after converting to Bielsa’s position, before ending the season with new Lille manager Christophe Galtier playing as a winger.
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Pepe was born on February 26, 1983, in Maceio, Alagoas, Brazil. He began his footballing career as a youth player at the Brazilian club Corinthians Alagoano before moving to Portugal with his family at the age of 18. All Electrical Items are sold as parts and should be certified by a Qualified Electrician before use.
B. Erik, H. Havitcioglu, S. Aktan and N. Karakus, Skin Res. Technol., 2008, 14, 147–151 CrossRef PubMed.M. V. R. Velasco, T. C. d S. Dias, A. Z. De Freitas, N. D. V. Júnior, C. Aparecida Sales de Oliveira Pinto, T. M. Kaneko and A. R. Baby, Braz. J. Pharm. Sci., 2009, 45, 153–162 CrossRef. The hair's physical structure and the interactions between hair components endow the hair with remarkable mechanical properties. Chemical over-bleaching affects both the hair's structure and its interactions, leading to a significant loss of strength and elasticity. 11,61,62 The treatment of the hair fibres with the peptides may re-establish some of the hydrogen and disulphide bonds lost during chemical treatment, improving the hair's mechanical properties. The effect of the peptides on the hair's mechanical properties was assessed through the evaluation of hair elasticity (Young's modulus) and stress at peak ( Fig. 3C). The Young's modulus results from α-keratin stretching, which is resisted by disulphide bonds and by hydrogen bonds between turns that stabilize the helical structure of the keratin. After α-keratin stretching, a transition of the keratin from α-helix to β-sheet occurs, in which the keratin chains unfold without a high level of resistance. The measurement of the stress at peak corresponds to the resistance of β-sheets to stretch until reaching the rupture point. 63–65 b) The Auctioneer has the right at his absolute discretion to withdraw or divide any lot or to combine any two or more lots.
Straightening evaluation of curly hair tresses treated with peptides in serum formulation. The efficiency of the peptides at straightening curly hair was evaluated in an alcoholic-based formulation. The effect of the formulation was computationally reproduced in a previous study regarding strong interactions between the hair and alcoholic components. 55 The peptides (PepE, PepG and KP) were incorporated into alcoholic formulations at pH 7.5 (1.5% propylene glycol, 10% ethanol, and 0.5% benzyl alcohol). Each serum formulation was applied onto the hair tresses and left in for 15 minutes. The hair straightening process was induced using a flat iron at 200 °C. The method was repeated until each hair tress was dried and straight. Then, the hair tresses were washed with distilled water and dried at 50 °C. The straightening efficiency was calculated using the above-mentioned equation. The hair tresses were then washed and shampooed 20 times. Results and discussion Characteristics of chosen peptides The modification of hair shape was the driving force for the selection of appropriately engineered peptides based on the sequences of keratin and KAPs. These peptides were selected based on a previous study of 1235 cysteine-containing peptides of all genes of human hair keratin and KAPs. 34 This study analysed the interaction of the peptides with keratin extracted from human hair, and the peptides with the best characteristics were selected for further analysis. Due to their high cysteine content and hydrophobic properties, these peptides are expected to present higher affinities towards the hair proteins. Furthermore, decapeptides are small enough to be able to penetrate into the hair cortex, but 10 to 13 amino acids residues make these peptides big enough to provide enhancement of strength and restructuring of the hair protein linkage network. 10,16,30,32 G. Loussouarn, A.-L. Garcel, I. Lozano, C. Collaudin, C. Porter, S. Panhard, D. Saint-Léger and R. de La Mettrie, Int. J. Dermatol., 2007, 46(suppl. 1), 2–6 CrossRef PubMed. Nicolas Pépé is a professional footballer who plays as a winger for the Premier League club Arsenal. Born in France, he represents the Ivory Coast national team. Do you want to know whether Nicolas Pépé is married or unmarried In this section, we will talk about Nicolas Pépé’s personal life and life story. As you are curious to know about his girlfriend. We added the information below. Marital StatusOn 28 June, he scored his first FA Cup goal in a 2–1 away win against Sheffield United in the quarter-finals, giving Arsenal the lead in the 25th minute from the spot. penalty. On 1 August, he played the full 90 minutes of the FA Cup Final against Chelsea to win his first club trophy as an Arsenal player, contributing the assist for Aubameyang’s second goal. Off the field, Pepe is known for his charitable work, particularly in his home country of Brazil. He has supported causes related to education, health, and poverty alleviation, and has also been involved in initiatives to promote football among underprivileged youth.
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