Virbac Anxitane Tablets, Small Dog/Cat, 50Mg, 30 Count

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Although the relaxing activity of L-theanine has been shown in humans, laboratory animals and dogs, it has not been published in cats. Cats can show undesirable behaviours when experiencing stressful events, such as urinary marking of furnitures and household structures, excessive scratching, aggressiveness and overgrooming. In addition to these behavioural changes, stress can also lead to recurring physical conditions such as emotional (often qualified as idiopathic) cystitis, chronic digestive signs (vomiting, diarrhoea) and disturbed eating behaviours [ 22, 23, 24]. From the pet owner’s stand point, the most unwanted behaviours are urinary marking [ 25, 26] and excessive scratching [ 27], which are usually the first signs of discomfort. Before the situation worsens and requires medication, it would be useful to determine if an oral supplement containing L-theanine can reduce stress-related behaviours as in the other species studied so far. Amat M, Camps T, Manteca X. Stress in owned cats: behavioural changes and welfare implications. J Feline Med Surg. 2016;18(8):577–86. ThunderShirt Anxiety Shirt for Dogs is an effective and safe solution for calming fearful and anxious dogs. It is ideal for fear of fireworks, thunderstorms, separation anxiety, cars or travelling. The Thundershirt is easy to put on and ensures a consistent pressure on the core of the dog. This pressure has a calming effect for most dogs. In a recent survey of over a 1000 users, 85% of dogs were less anxious when wearing the shirt (The Journal of Veterinary Science). The product itself was then evaluated for acceptability, tolerance and owner satisfaction. The first two parameters were scored from 1 (very good) to 4 (poor). Statistical analysis Anxitane’s insert states that it is not intended for use in dogs with severe phobias, separation anxiety, or a history of aggression.

Kern L. La transmission de la peur. In: Beata C, ed. La Communication. Collection Zoopsychiatrie. Marseille, France: Solal Editeurs; 2005:191–196. Li C, Tong H, Yan Q, Tang S, Han X, Xiao W, Tan Z. L-Theanine improves immunity by altering TH2/TH1 cytokine balance, brain neurotransmitters, and expression of phospholipase C in rat hearts. Med Sci Monit. 2016;22:662–9. Use Anxitane M & L - 100 mg tablets. Long-term administration: 1 tablet twice daily Episodic administration: 1 tablet 12 hours and 2 hours before the event and 1 tablet every 6 hours during the event. Nathan PJ, Lu K, Gray M. The neuropharmacology of L-theanine (N-Ethyl-L-Glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006;6(2):21–30. Thirty-three privately owned cats presenting signs associated with stress or fear (inappropriate urination/defecation, fear-induced aggressiveness, hypervigilance/tenseness or physical/functional manifestations of stress) for at least 1 month, were included in the study. They were given L-theanine (Anxitane®, 25 mg twice a day) for 30 days and 20 stress-related parameters were scored at Days 0, 15 and 30. The evolution of some parameters was also rated relative to Day 0. All median scores of the 20 parameters were significantly reduced at D30, and 30/33 cats (91%) had a reduced global score at the end of the study, including 21/33 with ≥50% score reduction. The median (IQR) global scores went from 18 (13–23) at D0 to 11 (8–13) at D15 and 5 (3–12) at D30 ( p< 0.0001; Friedman test; significant reduction starting from D15). All the stress-related signs were significantly improved compared to D0, according to the owners, especially inappropriate elimination. Tablet palatability was judged good or very good in 94% of cases with spontaneous intake by cats when given by hand or in food. Tolerance was satisfactory as well, and no side effects were reported, so that most owners (27/33; 82%) were satisfied with the product. ConclusionsAraujo JA, De Rivera C, Ethier JE, Landsberg GM, et al. Anxitane tablets reduce fear of human beings in a laboratory model of anxiety-related behavior. J Vet Behav. 2010;5:268–75. The ability to increase mental focus and learning abilities; great to use during behavioural training 1,2,3 Nobre AC, Anling R, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17(suppl 1):167–168. All the parameters significantly improved (lower score) during the course of the study, except for those which concerned too few animals (< 4 cats: diarrhoea, hypersalivation and redirected aggression). Hypervigilance/hyperesthesia was the parameter with the highest median score at D0 and concerned 27/33 cats (82%). A significant decrease of this median (IQR) score was observed during the course of the study: from 3 (2–3), to 1 (0–2) and 1 (0–1) at D0, D15 and D30 respectively ( p< 0.0001). At the end of the study, 8/27 cats (30%) no longer showed the signs. Shivering was the parameter most reduced in frequency since it was detected in 11/33 cats (33%) at the beginning of the trial and in only 3/33 cats (9%) by the end of the study. Feliway Optimum Diffuser calms cats better than ever, and in more situations for enhanced serenity. It contains a new feline pheromone complex that conveys even more impactful messages to your cat which helps them cope with our modern lifestyles. Cats naturally produce pheromones, some of which are invisible calming messages. Feliway Optimum contains the most advanced Feline Pheromones Complex, developed by the Feliway research team.

Gagnon AC, Chaurand JP, Larue JF. Le comportement du chat et ses troubles. Maisons-Alfort: Editions du point vétérinaire; 1995. p. 288. In humans, L-theanine has been shown to facilitate the generation of alpha waves in the brain that are indicative of a relaxed, awake and alert state, without promoting drowsiness [ 2, 7, 8, 9]. L-theanine would also help regulate the physiological parameters usually increased during stressful events (e.g. blood pressure, heart rate, cortisol secretion), which further contributes to the stress-reducing effects [ 9, 10, 11, 12]. L-theanine’s relaxing effect has also been shown in dogs with fear of humans [ 13] or storms [ 14]. After 1 or 2 months of L-theanine administration (twice a day), fearful reactions were reduced. Finally, L-theanine would enable the increase of learning capacities [ 15, 16]. The scores for the 20 parameters were added to calculate a global score reflecting the presence of undesirable behaviours possibly related to stress in test animals. Anxitane ™ minimerer stress og utryghed i stressende situationer såsom ved gæstebesøg, flytning, ferie, dyrlægebesøg, tordenvejr m.m. Tabletterne hjælper indenfor kort tid dit kæledyr med igen at finde ro. Although no study describing the mechanism of action of L-theanine in cat is available, it is highly likely that it is similar to what was described earlier in laboratory animals (especially, an action on glutamate receptors and release of neuromediators) [ 4, 17, 19, 21]. More specifically, no sedative effect of L theanine has been previously reported in human, in rats, nor in dogs [ 2, 7, 8, 13, 14] .Therefore we expect that the effects observed in this study are due to a decrease of the stress level (and not to a sedative effect).

The risk is increased in dogs with hypotension or when L-theanine is given with drugs which reduce blood pressure. De velsmagende tyggetabletter er lette at anvende og indtages gerne af selv kræsne hunde og katte. Produktfordele:

Yamada T, Terashima T, Honma H, Nagata S, Okubo T, Juneja LR, Yokogoshi H. Effects of theanine, a unique amino acid in tea leaves, on memory in a rat behavioral test. Biosci Biotechnol Biochem. 2008;72(5):1356–9. Terashima T, Takido J, Yokogoshi H. Time-dependent changes of amino acids in the serum, liver, brain and urine of rats administered with theanine. Biosci Biotechnol Biochem. 1999;63(4):615–8. Here are some of the best calming products for dogs and cats. Natural ingredient based calming supplements 1) Zylkene In 4 published studies ANXITANE Chewable Tablets administration produced significant reductions in anxiety scores in cats and dogs Yokogoshi H, Mochizuki M, Saitoh K. Theanine-induced reduction of brain serotonin concentration in rats. Biosci Biotechnol Biochem. 1998;62(4):816–7.Understanding the differences between the products and knowing more about the active calming ingredient within them can help you make the best choice for your pet. It may be that one doesn’t appear to work so well for your dog or cat. In this case, you’ll be able to make an informed choice about an alternative product which uses a different method of calming or ingredient. The main reasons for inclusion were stress-related behavioural signs (hypervigilance, nervousness, fear) in 79% of the cases and inappropriate elimination (45% of the cases) while aggressiveness (24% of the cases) and stress-induced functional/organic signs (mainly changes in feeding or drinking behaviour; 21% of the cases) occurred less often (Table 1). The median (range) age of onset of undesirable behaviours/signs was 1 (0.2–12) year with 67% and 15% of the cats starting to show issues before the age of 1 and from adoption, respectively. In 42% of the cats, such behaviours had been stable since their onset, but had worsened over time in another 58% of the cats. Scores of stress-related parameters Many pets suffer with stress and anxiety, whether it’s caused by holidays, kennel or cattery stays, trips to the vet, new additions to the household, or fireworks. It can be tough to see your pet display the signs of stress, but there is a range of calming products for dogs and cats available. These products are specially designed to help your pet cope better. Open field trials showed ANXITANE ® (L-Theanine) Chewable Tablets to be an effective solution for environmentally induced stress in dogs and cats 8,9 Yokogoshi H, Terashima T. Effect of theanine, γ-glutamylethylamide, on brain monoamines, striatal dopamine release and some kinds of behavior in rats. Nutrition. 2000;16:776–7.

Kakuda T, et al. Inhibition by theanine of binding of [3H]AMPA, [3H]Kainate, and [3H]MDL 105,519 to glutamate receptors. BiosciBiotechnol Biochem. 2002;66:2683–6. L-theanine (found in Composure and Anxitane) is a type of amino acid with some evidence to show it is effective at reducing anxiety in dogs. Because of its safety, and the low risk of side effects, it is a popular remedy for owners who don’t want to give their dog medicines like Xanax. It is thought to increase levels of dopamine and GABA in the brain, though there is differing opinions on how the substance affects serotonin levels. These chemicals play a role in mood, and can affect how anxious a dog feels.Juneja LR, Chu DC, Okubo T, Nagato Y, Yokogoshi H. L-theanine-a unique amino acid of green tea and its relaxation effect in humans. Trends Food Sci Technol. 1999;10:199–204. faq_q1: Hvilken type Anxitane™ passer til mit kæledyr? faq_a1: • Anxitane™ S anvendes til katte og små hunde under 10 kg Yokogosi H, Kobayashi M, Mochizuki M, Terashima T. Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Neurochem Res. 1998;23:667–673. CAUTIONS: Safe use in pregnant animals or animals intended for breeding has not been proven. If the animal’s condition worsens or does not improve after 60 days of use, stop product administration and consult your veterinarian. Not intended for use in animals with severe phobias, separation anxiety or in animals with a known history of aggression.