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Our study showed that the administration of Parkinson’s drugs (Benserazide and dopamine agonists) along with probiotics significantly improved patients’ UPDRS-III scores. Similar observations were reported in previous works 24, 34. One possible mechanism of probiotic-driven alleviation of PD-related symptoms was the increase in activity of tyrosine hydroxylase, which is a key factor for L-tyrosine-L-dopa transformation 35. Apart from motor symptoms, constipation is prevalent in patients with PD, and it might have occurred 15–24 years before the diagnosis of PD 36. Our literature search identified only six studies that investigated the beneficial effect of probiotic administration/ probiotic fermented milk on patients with PD 23, 24, 25, 26, 27, 28, and four of which indicated that probiotic consumption increased Bristol scores and improved defecation habits 23, 25, 26, 27. As expected, our data showed that administering Probio-M8 also improved stool consistency, the number of spontaneous and completed defecation per week, parameters of difficulty in defecation, incomplete defecation, assisted defecation by hand, times of drain, and hardening of stool, and the scores of PA-CQL. Gefenaite, G. et al. Longitudinal association between housing accessibility and activities of daily living: the role of self-efficacy and control in people ageing with Parkinson’s disease. BMC Geriatr. 20, 181 (2020). You can find probiotics in supplements and some foods, like yogurt. Doctors often suggest them to help with digestive problems. Kim, C. S. et al. Probiotic supplementation improves cognitive function and mood with changes in gut microbiota in community-dwelling older adults: a randomized, double-blind, placebo-controlled, multicenter trial. J. Gerontol. Ser. A Biol. Sci. Med. Sci. 76, 32–40 (2021). Bifidobacterium. You can find it in some dairy products. It may help ease the symptoms of irritable bowel syndrome (IBS) and some other conditions.
Germains Seed Technology recently introduced ProBio® gopure®, a new organic seed disinfection process that removes bacterial seed-borne pathogens such as Bacterial Leaf Spot from Swiss chard, red beet, and coriander seeds. You can also get probiotics in less concentrated quantities from fermented foods and drinks, including: A general recommendation is to choose probiotic products with at least 1 billion colony-forming units and containing the genus Lactobacillus, Bifidobacterium, Bacillusor Saccharomyces boulardii, some of the most researched probiotics. Even then, you may have to delve deeper, as each genus of bacteria encompasses numerous strains that produce different results.
Deng, H. Y. et al. Efficacy of probiotics on cognition, and biomarkers of inflammation and oxidative stress in adults with Alzheimer’s disease or mild cognitive impairment - a meta-analysis of randomized controned trials. Aging 12, 4010–4039 (2020).
Zhao, X. Y. et al. Baicalein alleviates depression-like behavior in rotenone- induced Parkinson’s disease model in mice through activating the BDNF/TrkB/CREB pathway. Biomed. Pharmacother. 140, 11 (2021). Many probiotic products are formulated with beneficial bacteria and yeasts for the purpose of preventing or recovering from bacterial or yeast infections in your different body parts, including: Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs; Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, 010018, ChinaGut microbiota-originated metabolites were predicted by MelonnPan. A total of 80 metabolites were identified, and deoxycholic acid and glutamate were the most abundant metabolites. Procrustes analysis is a statistical method that displays multi-omics datasets in low-dimensional space after data dimensionality reduction, and it has been increasingly used in microbiome and metabolomics research to evaluate the cohesiveness between datasets 33. The concordance between the gut microbiome and predicted metabolome was evaluated by Procrustes analysis, and positive cooperativity was found between the two datasets (correlation = 0.329, P = 0.001, Fig. 4b). Changes in patients’ gut metabolome were assessed by PCoA analysis, and no specific time-based clustering pattern was observed on the PCoA score plots of both groups (Fig. 4c, d). However, significant difference was found in the gut microbiota community between time points in Probio-M8 (baseline versus 1 M, P = 0.233, R = 0.006; baseline versus 3 M, P = 0.003, R = 0.075; adonis test; Fig. 4d) but not placebo group (Fig. 4c). While this is specifically a travel product, we love it because it contains three broad strains and is formulated for the purpose of preventing travellers diarrhea.
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