Canesflor Vaginal Probiotics | Helps Prevent Recurrence of Vaginal Infections such as Thrush | Clinically Proven - 10 Count (Pack of 1)

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estrogen and progesterone HRT, only 1 to 3 species of bacteria, mainly Lactobacillus, were detected in the vaginal To summarize, most of the current BV clinical trials did not use Lactobacillus species from the vaginal tract. These data collectively indicate that L. crispatus could be of potential use for BV treatment and that a rigorous pre-clinical screening strategy needs to be applied to identify the best strains that can maximize adaptiveness and colonization in the vaginal environment. The proper Lactobacillus species from a vaginal microbiome should also be tested in large, randomized, placebo-controlled cohorts. Consideration 2: administration method

Blaser, M. J. Fecal microbiota transplantation for dysbiosis—predictable risks. N. Engl. J. Med. 381, 2064–2066 (2019).with indigenous organisms. Some species found in the gut, such as E. coli and Streptococcus, can also be found in the vagina, indicating the The advantages of treatment with antibiotics are their availability and convenience for clinical use. Patients can easily administer antibiotics at home with instruction. Also, since BV is characterized by the overgrowth of anaerobic bacteria, reduced vaginal bacterial load following antibiotic treatment may provide the chance for Lactobacillus species to compete for nutrients and biological niches again. Overall, a large proportion of women with BV have been cured after one-time treatment in a short period of time 27, 33, 34. Second, suitable regulatory aspects related to the production and marketing of VMT and vaginal probiotics should be in place. Vaginal administration leads to products not classified as dietary supplements. Being classified into personal care products or being prescribed to patients as drugs needs more restrictive regulation and report adverse events 91, 93. In this regard, professional medical associations should issue recommendations concerning the role of VMT and probiotics in obstetrics and gynecology, as their uncontrolled implementation might also lead to a potential decrease in effectiveness. Detailed discussions on medical and regulatory considerations, including finding the right FDA regulatory path for VMT, are of crucial importance for future clinical trials of VMT and have been reviewed in other papers 69, 94. BV prevalence varies geographically and ethnically, and can affect >50% of women in some countries 6. BV is diagnosed using Amsel’s criteria or Nugent score, with Amsel’s criteria more commonly used in the clinic 5. Amsel’s criteria combines inspection of vaginal secretions, pH measurement, visual inspection under microscopy, and the Whiff test, whereas the Nugent score focuses exclusively on scoring Gram-stained microscopy images. The BV definition based on DNA sequencing of vaginal secretions is referred to as molecular BV 7, 8. susceptible to UTI, it was discovered that immunological defects in peripheral blood coexisted with a persistently

detecting sialidase produced by pathogens associated with the condition [ 49, 50]. Of note, aerobic vaginitis has also been Ravel, J. et al. Vaginal microbiome of reproductive-age women. Proc. Natl. Acad. Sci. USA 108, 4680–4687 (2011).Turhan, N. Ö. & Seçki̇n, N. C. Garnerella-associated vaginitis: comparison of three treatment modalities. Turk. J. Med. Sci. 28, 171–174 (1998). Bohbot, J. M. et al. Efficacy and safety of vaginally administered lyophilized Lactobacillus crispatus IP 174178 in the prevention of bacterial vaginosis recurrence. J. Gynecol. Obstet. Hum. Reprod. 47, 81–86 (2018).

Caretto M., Giannini A., Russo E., Simoncini T. (2017). Preventing urinary tract infections after menopause without antibiotics. Maturitas 99, 43–46. doi: 10.1016/j.maturitas.2017.02.004 Devoto, A. E. et al. Megaphages infect Prevotella and variants are widespread in gut microbiomes. Nat. Microbiol 4, 693–700 (2019).Stapleton, A. E. et al. Randomized, placebo-controlled phase 2 trial of a Lactobacillus crispatus probiotic given intravaginally for prevention of recurrent urinary tract infection. Clin. Infect. Dis. 52, 1212–1217 (2011). Other possibilities that could replace antibiotics as vaginosis treatment or pretreatment should also be evaluated. Isolating bacteriophages is a well-established technology, and bacteriophages targeting BV-related bacteria can be used alone or in combination with probiotics 77. Previous studies have identified that Lactobacillus bacteriophages are related to BV, and a higher load of Lactobacillus bacteriophages was found in vaginal microbiome samples among women with BV compared to healthy women 78, 79. However, although there have been bacteriophages against Gardnerella and Clostridium reported by sequencing, no lytic bacteriophage has been isolated by culturing 80. Furthermore, bacteriophages targeting Prevotella have been reported in the gut, but whether bacteriophages targeting vaginal Prevotella and other BV-related bacteria exist should be further studied 80. Cohen, C. R. et al. Randomized trial of lactin-V to prevent recurrence of bacterial vaginosis. N. Engl. J. Med. 382, 1906–1915 (2020). yoghurt containing L. acidophilus at > 1.0 × 10 8 colony-forming units ( n = 23). Yoghurt was consumed