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How to recycle: Remove the lid from the tube. Wash out the tube and dry. Both our lids and tubes are 100% recyclable so can be disposed of in your domestic recycling. Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutrition Journal. 2015;15(1). doi:10.1186/s12937-016-0130-8 Litwiniuk M, Krejner A, Speyrer MS, Gauto AR, Grzela T. Hyaluronic acid in inflammation and tissue regeneration. Wounds. 2016;28(3):78-88. Yang Z, Li M, Xiao L, Yi Z, Zhao M, Ma S. Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis. Brazilian Journal of Medical and Biological Research. 2020;53(8):e9886. doi:10.1590/1414-431X20209886
Lephart ED, Naftolin F. Menopause and the skin: old favorites and new innovations in cosmeceuticals for estrogen-deficient skin. Dermatology and Therapy. 2020;11(1):53-69. doi:10.1007/s13555-020-00468-7
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Abdulkareem AA, Al Marah ZA, Abdulbaqi HR, Alshaeli AJ, Milward MR. A randomized double‐blind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilm‐induced gingivitis. International Journal of Dental Hygiene. 2020;18(3):268-277. doi:10.1111/idh.12432 Abdallah MM, Fernández N, Matias AA, Bronze M do R. Hyaluronic acid and chondroitin sulfate from marine and terrestrial sources: extraction and purification methods. Carbohydrate Polymers. 2020;243:116441. doi:10.1016/j.carbpol.2020.116441 Oe M, Sakai S, Yoshida H, et al. Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Clinical, Cosmetic and Investigational Dermatology. 2017;10:267-273. doi:10.2147/CCID.S141845 Marinho A, Nunes C, Reis S. Hyaluronic acid: a key ingredient in the therapy of inflammation. Biomolecules. 2021;11(10):1518. doi:10.3390/biom11101518
Majeed M, Majeed S, Narayanan NK, Nagabhushanam K. A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Phytotherapy research: PTR. 2019;33(5):1457-1468. doi:10.1002/ptr.6338
Unfer V, Tilotta M, Kaya C, et al. Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy: a matter of molecular weight. Expert Opinion on Drug Metabolism & Toxicology. 2021;17(7):823-840. doi:10.1080/17425255.2021.1931682 Children: Studies have been performed to evaluate the efficacy of HA inhalation in the treatment of the upper and lower airways in children, but evidence of such efficacy is limited. Moreover, topical HA gel has been studied in children to treat mouth ulcers. Despite the use of HA in children, the safety of the consumption of HA by mouth in children is yet to be known. Ingredients: Aqua (Water), Propylene Glycol, Betaine, Sodium Hyaluronate, Biosaccharide Gum-1, Caprylyl Glycol, Lactic Acid, Sodium Gluconate, Glycerin, Phenoxyethanol, Sodium Levulinate, Glyceryl Caprylate, Sodium Anisate, Xanthan Gum Gocmen G, Aktop S, Tüzüner B, Goker B, Yarat A. Effects of hyaluronic acid on bleeding following third molar extraction. J Appl Oral Sci. 2017;25(2):211-216. doi:10.1590/1678-77572015-0187 Osteoarthritis: In a randomized study comparing the effect of intra-articular (within the joint) HA injection to betamethasone injection, people with osteoarthritis of the thumb underwent one cycle of three injections (one per week) of 0.5 cubic centimeters (cm 3) of HA 5 milligrams (mg). Intra-articular HA injection requires a prescription and is given as a shot to your knee joint by a trained healthcare professional.
Oliviero F, Ramonda R, Hoxha A, et al. Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. A pilot study. Reumatismo. 2020;72(3):125-130. doi:10.4081/reumatismo.2020.1272 Jang KM, Park YG, Choi WK, et al. Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study. Current Medical Research and Opinion. 2021;37(9):1573-1580. doi:10.1080/03007995.2021.1950132 Mikosinski J, Di Landro A, Kasztalska-Kazmierczak K, et al. Efficacy and safety of a hyaluronic acid-containing cream in the treatment of chronic, venous, or mixed-origin leg ulcers: a prospective, multicenter randomized controlled trial. Wounds. 2021;33(11):285-289. Simental-Mendía M, Sánchez-García A, Vilchez-Cavazos F, Acosta-Olivo CA, Peña-Martínez VM, Simental-Mendía LE. Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials. Rheumatology International. 2018;38(8):1413-1428. doi:10.1007/s00296-018-4077-2 Peanpadungrat P. Efficacy and safety of fish oil in treatment of knee osteoarthritis. J Med Assoc Thai. 2015;98( Suppl 3):S110-S114.Urinary tract infections: A study conducted in 10 children aged 2 to 18 years with spina bifida and neurogenic bladder who performed clean intermittent catheterization (a technique for bladder drainage) showed that the instillation of 40 milligrams (mg) HA into the bladder weekly for four weeks then monthly for the following three months reduced symptomatic recurrent urinary tract infections. However, further multicenter randomized, controlled clinical trials with larger sample sizes and longer follow-ups are needed to confirm such promising results. Maheu E, Rannou F, Reginster JY. Efficacy and safety of hyaluronic acid in the management of osteoarthritis: evidence from real-life setting trials and surveys. Seminars in Arthritis and Rheumatism. 2016;45(4):S28-S33. doi:10.1016/j.semarthrit.2015.11.008 Ibraheem W, Jedaiba WH, Alnami AM, et al. Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study. Eur Rev Med Pharmacol Sci. 2022;26(10):3444-3449. doi:10.26355/eurrev_202205_28838 Hyaluronic Acid Crosspolymer helps draw moisture into the skin and holds it safely in the upper layers of the skin to keep you looking fresh and hydrated. Polyglutamic Acid pairs perfectly with Hyaluronic Acid and helps draw even more moisture into the skin by forming a protective barrier that reduces moisture loss throughout the day - they are the ultimate pairing for dry and dehydrated skin. In addition, a unique Rice Bran extract delivers plenty of antioxidants and soothing Vitamin E for protection against environmental stressors and keeping your complexion feeling super soft.
Q+A Hyaluronic Acid Facial Serum works perfectly with Q+A Collagen Face Cream and Q+A Caffeine Eye Serum, giving you an ideal regime for dry or mature skin. Ingredients Cancer: Hyaluronic acid has been shown to facilitate metastasis in colorectal cancer in laboratory models. However, it is unclear how this may translate into “real-life” settings. If you have a history of cancer, do not use hyaluronic acid supplements without consulting your healthcare provider. Kim JS, Lee SS, Kim TJ, Park YW. Serum hyaluronic acid levels do not explain morning stiffness in patients with fibromyalgia. Clinical Rheumatology. 2010;29(5):535-539. doi:10.1007/s10067-010-1372-z Jun JH, Bang SP, Park HS, et al. A randomized multicenter clinical evaluation of sequential application of 0.3% and 0.15% hyaluronic acid for treatment of dry eye. Jpn J Ophthalmol. 2022;66(1):58-67. doi:10.1007/s10384-021-00885-x
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Monfort J, Rotés-Sala D, Segalés N, et al. Comparative efficacy of intra-articular hyaluronic acid and corticoid injections in osteoarthritis of the first carpometacarpal joint: results of a 6-month single-masked randomized study. Joint Bone Spine. 2015;82(2):116-121. doi:10.1016/j.jbspin.2014.08.008
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