Bee Health Propolis Lozenges 114 g Pack of 2

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Martinotti S, Ranzato E. Propolis: A new frontier for wound healing? Burns & Trauma. 2015;3:s41038-015-0010-z. doi:10.1186/s41038-015-0010-z Ngatu NR, Saruta T, Hirota R, et al. Brazilian green propolis extracts improve Tinea pedis interdigitalis and Tinea corporis. J Altern Complement Med. 2012;18(1):8-9. View abstract.

Esposito C, Garzarella EU, Bocchino B, et al. A standardized polyphenol mixture extracted from poplar-type propolis for remission of symptoms of uncomplicated upper respiratory tract infection (URTI): a monocentric, randomized, double-blind, placebo-controlled clinical trial. Phytomedicine 2021;80:153368. View abstract. Honey and propolis provide beneficial effect on human health. Since ancient times propolis has been extensively employed by man, especially in folk medicine to treat several maladies. Egyptians used bee glue to embalm their cadavers as they well knew about its putrefactive properties. Incas employed propolis as an antipyretic agent. Greek and Roman physicians used it as mouth disinfectant and as an antiseptic and healing product in wound treatment, prescribed for topical therapy of cutaneous and mucosal wounds [ 2]. Propolis was listed as an official drug in the London pharmacopoeias of the 17th century. Due to its antibacterial activity, in Europe propolis became very popular between the 17th and 20th centuries. In Italy bee glue was used as a violin varnish [ 3] by Stradivari. In the end of the 19th century, propolis was widely used due to its healing properties and in the Second World War it was employed in several Soviet clinics for tuberculosis treatment, due to the observed decline of lung problems and appetite recovery. In the Balkan states propolis was applied to treat wounds and burns, sore throat, and stomach ulcer [ 4]. The first scientific work with propolis was published in 1908 including its chemical properties and composition which was further indexed to chemical abstract [ 5]. Propolis has been widely used in natural therapeutic products because of its purported antiseptic, anti- inflammatory, anaesthetic and anti-oxidant properties. Davoodi SH, Yousefinejad V, Ghaderi B, et al. Oral propolis, nutritional status and quality of life with chemotherapy for breast cancer: a randomized, double-blind clinical trial. Nutr Cancer 2022;74(6):2029-2037. View abstract.Protective potential of propolis was evaluated against mercury-induced oxidative stress and antioxidant enzymatic alteration in mice liver. Exposure to mercuric chloride (HgCl 2; 5mg/kg; i.p.) induced oxidative stress by increasing lipid peroxidation and oxidized glutathione level along with concomitant decrease in glutathione and various antioxidant enzymes. Mercury intoxication deviated the activity of liver marker enzyme in serum. Conjoint treatment of propolis (200mg/kg; p.o.) inhibited lipid peroxidation and oxidized glutathione level whereas increased glutathione level. Activity of antioxidants enzymes, that is, superoxide dismutase, catalase, glutathione S-transferase, and glucose 6-phosphate dehydrogenase, was also restored concomitantly toward control after propolis administration. Release of serum transaminases alkaline phosphatase, lactate dehydrogenase, and γ-glutamyl transpeptidase was significantly restored toward control after propolis treatment. Results suggest that propolis augments the antioxidant defense against mercury-induced toxicity and provides evidence that it has therapeutic potential as hepatoprotective agent [ 59]. Giammarinaro E, Marconcini S, Genovesi A, Poli G, Lorenzi C, Covani U. Propolis as an adjuvant to non-surgical periodontal treatment: a clinical study with salivary anti-oxidant capacity assessment. Minerva Stomatol. 2018;67(5):183-188. View abstract. Be cautious with this combination • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with PROPOLIS Smoking Cessation Local stop smoking services are free, friendly and can massively boost your chances of quitting for good. These services staffed by expert advisers provide a range of proven methods to help you quit. They’ll give you accurate information and advice, as well as professional support, during the first few months you stop smoking. They also make it easy and affordable for you to get stop smoking treatments, such as: * Varenicline (Champix) * Bupropion (Zyban) * nicotine replacement therapy, such as patches and gum One-to-one and group stop smoking sessions You’ll normally be offered a one-to-one appointment with an adviser, but many areas also offer group and drop-in services as well. Depending on where you live, the venue could be a local GP surgery, pharmacy, high-street shop, or even a mobile bus clinic. Jennifer Percival, who trains stop smoking advisers, says that using both treatment and specialist support is proven to give you the best chance of stopping smoking. “The majority of people who see an adviser will get through the first month after quitting without smoking a cigarette. “Overall, you’re up to 4 times more likely to stop smoking for good if you use a combination of stop smoking…

Schnitzler P, Neuner A, Nolkemper S, et al. Antiviral activity and mode of action of propolis extracts and selected compounds. Phytother Res. 2010;24 Suppl 1:S20-S28. doi:10.1002/ptr.2868 Park JY, Ko KA, Lee JY, et al. Clinical and Immunological Efficacy of Mangosteen and Propolis Extracted Complex in Patients with Gingivitis: A Multi-Centered Randomized Controlled Clinical Trial. Nutrients 2021;13(8):2604. View abstract.

Feiks FK. Topical application of propolis tincture in the treatment of herpes zoster. Third International Symposium on Apitherapy 1978;109-111. The antitumor activity of propolis was reviewed by Orsolic et al. The chemopreventive activity of propolis in animal models and cell cultures is likely to be the result of their ability to inhibit DNA synthesis in tumour cells, their capability to induce apoptosis of tumour cells, and their property to activate macrophages to produce factors capable of regulating the function of B, T and NK cells, respectively. Moreover, these results suggest that flavonoids from propolis play a protective role against the toxicity of the chemotherapeutic agents or radiation in mice, giving hope that they may have similar protective action in humans. The combination with an adjuvant antioxidant therapy may enhance the effectiveness of chemotherapy by ameliorating the side effect on leukocytes, liver, and kidneys and consequently enabling dose escalation [ 63]. Although many polyphenols have an antimetastatic activity, caffeic acid phenethyl esters (CAPE) from poplar propolis and Artepillin C from Baccharis propolis have been identified as the most potent antitumor agents [ 64– 68]. Maichuk, I. F., Orlovskaia, L. E., and Andreev, V. P. [The use of ocular drug films of propolis in the sequelae of ophthalmic herpes]. Voen.Med Zh. 1995;12:36-9, 80. View abstract. Coutinho A. Honeybee propolis extract in periodontal treatment: a clinical and microbiological study of propolis in periodontal treatment. Indian J Dent Res. 2012;23(2):294. View abstract.

Kubat M, Karabulut Z, Sengül S. Effect of propolis on wound healing in sacrococcygeal pilonidal disease: a randomized controlled clinical trial. Pak J Pharm Sci 2021;34(3(Supplementary)):1063-7. View abstract. Patients with known allergies to conifer, poplar, salicylates and Myroxylon pereirae are advised to avoid propolis due to shared allergenic constituents. It is important to be aware of the names of propolis-related substances as these also should be avoided. Hoheisel O. The effects of Herstat (3% propolis ointment ACF ) application in cold sores: a double-blind placebo-controlled clinical trial. Journal of Clinical Research 2001;4:65-75. Water extracts of propolis collected from the three geographical regions (Motobes, Kafr El-Sheikh, and Desouk) in Kafr El-Sheikh Governorate, Egypt, were prepared. The extracts were analyzed for the determination of total polyphenols which ranged from 5.70 to 8.79g/100gm of the sample and from 22.80 to 34.30g/100g of the freeze drier extract. The total flavonoids content ranged from 3.05 to 4.85g/100g of the sample. Water extracts of propolis were evaluated for antioxidant activity using β-carotene bleaching and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay system. It was observed that all propolis had strong antioxidant activity due to their contents of total phenols and flavonoids. The highest activity was found for the sample from Desouk followed by these from Kafr El-Sheikh, then those from Motobes. Freeze-dried extract of propolis can be used as natural antioxidant in sunflower oil as compared to BHT and TBHQ. Propolis from Desouk and Kafr El-Sheikh at 200 and 300ppm were similar in reducing peroxide values and both of them at 300ppm were better than BHT but lower than TBHQ, added at 200ppm concentration, in reducing peroxides and hydroperoxidase production in sunflower oil at 63°C for 4 days [ 57].Arenberger P, Arenbergerova M, Hladíková M, Holcova S, Ottillinger B. Comparative Study with a Lip Balm Containing 0.5% Propolis Special Extract GH 2002 versus 5% Aciclovir Cream in Patients with Herpes Labialis in the Papular/Erythematous Stage: A Single-blind, Randomized, Two-arm Study. Curr Ther Res Clin Exp. 2017;88:1-7. View abstract.

De Vecchi, E. and Drago, L. [Propolis' antimicrobial activity: what's new?]. Infez.Med 2007;15(1):7-15. View abstract. Flavonoids and polyphenols may lower your risk of developing certain medical conditions, such as heart disease. Russo, A., Cardile, V., Sanchez, F., Troncoso, N., Vanella, A., and Garbarino, J. A. Chilean propolis: antioxidant activity and antiproliferative action in human tumor cell lines. Life Sci. 12-17-2004;76(5):545-558. View abstract.

Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed 2021;11(6):551-65. View abstract. Propolis is notable for its antioxidant properties. The antioxidants present in propolis [ 53, 54] play a great role in its immunomodulatory properties [ 55]. The flavonoids concentrated in propolis are powerful antioxidants. One of the most commonly used techniques to evaluate antioxidant potential is based on the depletion of free radicals by the addition of scavenger compounds. Measurements of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical consumption are related to the intrinsic ability of a substance or a complex mixture to donate hydrogen atoms or electrons to this reactive species in a homogeneous system. It was reported that propolis increases the cellular immune response through the increase of mRNA for interferon- γ and activates the production of cytokines [ 56]. Grange, J. M. and Davey, R. W. Antibacterial properties of propolis (bee glue). J R.Soc Med 1990;83(3):159-160. View abstract.