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In patients with renal impairment or those undergoing haemodialysis, the pharmacokinetic parameters of irbesartan are not significantly altered. Irbesartan is not removed by haemodialysis. In patients with creatinine clearance < 20 ml/min, the elimination half-life of hydrochlorothiazide was reported to increase to 21 hours. Rise of an Empire (2014)". Rotten Tomatoes. Archived from the original on March 23, 2018 . Retrieved July 6, 2023. Roberts, Sheila (March 18, 2014). "Junkie XL Talks 300, Divergent, Mad Max, Interstellar and More". Collider . Retrieved April 17, 2023. Adam Nayman (March 7, 2014). "300: Rise of an Empire: A brutal campaign with an Xbox aesthetic". Toronto: The Globe and Mail. Archived from the original on December 10, 2017 . Retrieved March 8, 2014.

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Epidemiological evidence regarding the risk of teratogenicity following exposure to ACE inhibitors during the first trimester of pregnancy has not been conclusive; however a small increase in risk cannot be excluded. Whilst there is no controlled epidemiological data on the risk with Angiotensin II Receptor Antagonists (AIIRAs), similar risks may exist for this class of drugs. Unless continued AIIRA therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy. When pregnancy is diagnosed, treatment with AIIRAs should be stopped immediately, and, if appropriate, alternative therapy should be started. Schaefer, Sandy (June 2, 2010). "First Look At '300′ Prequel Comic Book". ScreenRant. Archived from the original on January 30, 2013 . Retrieved February 1, 2013. The following changes, observed in rats and macaques receiving the irbesartan/hydrochlorothiazide combination at 10/10 and 90/90 mg/kg/day, were also seen with one of the two medicinal products alone and/or were secondary to decreases in blood pressure (no significant toxicologic interactions were observed): Multiply the divisor by the result in the previous step (12 x 2 = 24) and write that answer at the bottom:Rare cases of allergic skin reactions (rash, urticaria), as well as localised swelling of the face, lips and/or tongue have been reported in patients taking irbesartan. Sitterson, Aubrey. "Comic-Con 2011: Xerxes Is Now 300: Battle of Artemisia". UGO Networks. Archived from the original on February 19, 2013 . Retrieved February 1, 2013.

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Ann Hornaday (March 6, 2014). " '300: Rise of an Empire' movie review: Sequel is no fun at all". The Washington Post. Archived from the original on December 10, 2017 . Retrieved March 8, 2014. Five historical errors in the new film". BBC News. March 8, 2014. Archived from the original on September 2, 2018 . Retrieved June 21, 2018. Thiazides have been shown to increase the urinary excretion of magnesium, which may result in hypomagnaesemia. The effect of the combination of irbesartan and hydrochlorothiazide on morbidity and mortality has not been studied. Epidemiological studies have shown that long term treatment with hydrochlorothiazide reduces the risk of cardiovascular mortality and morbidity. sequel amps up blood, tamps down believability". Usatoday.com. February 18, 2014. Archived from the original on November 27, 2017 . Retrieved March 8, 2014.

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In Athens, Xerxes's army is laying waste when Ephialtes arrives to deliver Themistocles' message. Upon learning he is alive, Artemisia leaves to ready her navy for battle. The remaining Greek ships charge into the Persian ships, beginning the decisive Battle of Salamis. Themistocles and Artemisia engage in a duel, which ends in a stalemate with both receiving severe injuries. CoAprovel 150 mg/12.5 mg may be administered in patients whose blood pressure is not adequately controlled with hydrochlorothiazide or irbesartan 150 mg alone; a b Llewellyn-Jones, Lloyd (2018). "Trouble in the Tehran multiplex: Iranian perceptions of the heroic in 300 and 300 Rise of an Empire". In Augoustakis, Antony; Richie, Stacie (eds.). Epic Heroes on Screen. Edinburgh: Edinburgh University Press. p.199. Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.